Description

TB-500 is a synthetic version of the naturally occurring peptide found in virtually all human and animal cells, thymosin beta-4. This active peptide is part of a ubiquitous family of 16 related molecules with high conservation and localization of sequences in most circulating tissues and cells of the body. TB-500 not only binds actin but also blocks actin polymerization and is an actin sequestering molecule in eukaryotic cells.

TB-500 has been identified as a gene that has been upregulated four to six times during early blood vessel formation and has been shown to promote the growth of new blood cells from existing vessels. This peptide is found in wound fluid and, when administered subcutaneously, promotes wound healing, muscle building, and accelerates the recovery time of muscle fibers and cells. Another key factor for TB-500 is that it promotes cell migration through specific interaction with actin in the cell’s cytoskeleton. The small and long central actin-binding domain has been shown to have both blood cell reproductive and wound-healing properties. These properties are determined by accelerating the migration of endothelial cells and keratinocytes. It also increases the production of enzymes which break down the extracellular matrix.